diff --git a/ChangeLog.d/fix-tls-SuiteB.txt b/ChangeLog.d/fix-tls-SuiteB.txt
new file mode 100644
index 000000000..0be753ac5
--- /dev/null
+++ b/ChangeLog.d/fix-tls-SuiteB.txt
@@ -0,0 +1,3 @@
+Bugfix
+   * Remove accidental introduction of RSA signature algorithms
+     in TLS Suite B Profile. Fixes #8221.
diff --git a/include/mbedtls/ssl.h b/include/mbedtls/ssl.h
index 46a3829d4..36295269a 100644
--- a/include/mbedtls/ssl.h
+++ b/include/mbedtls/ssl.h
@@ -447,7 +447,7 @@
 
 /*
  * TLS 1.3 signature algorithms
- * RFC 8446, Section 4.2.2
+ * RFC 8446, Section 4.2.3
  */
 
 /* RSASSA-PKCS1-v1_5 algorithms */
diff --git a/library/ssl_tls.c b/library/ssl_tls.c
index 2470b7bef..8c1e37251 100644
--- a/library/ssl_tls.c
+++ b/library/ssl_tls.c
@@ -5118,23 +5118,17 @@ static uint16_t ssl_preset_default_sig_algs[] = {
     // == MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_ECDSA, MBEDTLS_SSL_HASH_SHA512)
 #endif
 
-#if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT) && \
-    defined(MBEDTLS_MD_CAN_SHA512)
+#if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT) && defined(MBEDTLS_MD_CAN_SHA512)
     MBEDTLS_TLS1_3_SIG_RSA_PSS_RSAE_SHA512,
-#endif \
-    /* MBEDTLS_X509_RSASSA_PSS_SUPPORT && MBEDTLS_MD_CAN_SHA512 */
+#endif
 
-#if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT) && \
-    defined(MBEDTLS_MD_CAN_SHA384)
+#if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT) && defined(MBEDTLS_MD_CAN_SHA384)
     MBEDTLS_TLS1_3_SIG_RSA_PSS_RSAE_SHA384,
-#endif \
-    /* MBEDTLS_X509_RSASSA_PSS_SUPPORT && MBEDTLS_MD_CAN_SHA384 */
+#endif
 
-#if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT) && \
-    defined(MBEDTLS_MD_CAN_SHA256)
+#if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT) && defined(MBEDTLS_MD_CAN_SHA256)
     MBEDTLS_TLS1_3_SIG_RSA_PSS_RSAE_SHA256,
-#endif \
-    /* MBEDTLS_X509_RSASSA_PSS_SUPPORT && MBEDTLS_MD_CAN_SHA256 */
+#endif
 
 #if defined(MBEDTLS_RSA_C) && defined(MBEDTLS_MD_CAN_SHA512)
     MBEDTLS_TLS1_3_SIG_RSA_PKCS1_SHA512,
@@ -5154,42 +5148,47 @@ static uint16_t ssl_preset_default_sig_algs[] = {
 /* NOTICE: see above */
 #if defined(MBEDTLS_SSL_PROTO_TLS1_2)
 static uint16_t ssl_tls12_preset_default_sig_algs[] = {
+
 #if defined(MBEDTLS_MD_CAN_SHA512)
 #if defined(MBEDTLS_KEY_EXCHANGE_ECDSA_CERT_REQ_ALLOWED_ENABLED)
     MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_ECDSA, MBEDTLS_SSL_HASH_SHA512),
 #endif
 #if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT)
     MBEDTLS_TLS1_3_SIG_RSA_PSS_RSAE_SHA512,
-#endif /* MBEDTLS_X509_RSASSA_PSS_SUPPORT */
+#endif
 #if defined(MBEDTLS_RSA_C)
     MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_RSA, MBEDTLS_SSL_HASH_SHA512),
 #endif
-#endif /* MBEDTLS_MD_CAN_SHA512*/
+#endif /* MBEDTLS_MD_CAN_SHA512 */
+
 #if defined(MBEDTLS_MD_CAN_SHA384)
 #if defined(MBEDTLS_KEY_EXCHANGE_ECDSA_CERT_REQ_ALLOWED_ENABLED)
     MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_ECDSA, MBEDTLS_SSL_HASH_SHA384),
 #endif
 #if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT)
     MBEDTLS_TLS1_3_SIG_RSA_PSS_RSAE_SHA384,
-#endif /* MBEDTLS_X509_RSASSA_PSS_SUPPORT */
+#endif
 #if defined(MBEDTLS_RSA_C)
     MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_RSA, MBEDTLS_SSL_HASH_SHA384),
 #endif
-#endif /* MBEDTLS_MD_CAN_SHA384*/
+#endif /* MBEDTLS_MD_CAN_SHA384 */
+
 #if defined(MBEDTLS_MD_CAN_SHA256)
 #if defined(MBEDTLS_KEY_EXCHANGE_ECDSA_CERT_REQ_ALLOWED_ENABLED)
     MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_ECDSA, MBEDTLS_SSL_HASH_SHA256),
 #endif
 #if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT)
     MBEDTLS_TLS1_3_SIG_RSA_PSS_RSAE_SHA256,
-#endif /* MBEDTLS_X509_RSASSA_PSS_SUPPORT */
+#endif
 #if defined(MBEDTLS_RSA_C)
     MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_RSA, MBEDTLS_SSL_HASH_SHA256),
 #endif
-#endif /* MBEDTLS_MD_CAN_SHA256*/
+#endif /* MBEDTLS_MD_CAN_SHA256 */
+
     MBEDTLS_TLS_SIG_NONE
 };
 #endif /* MBEDTLS_SSL_PROTO_TLS1_2 */
+
 /* NOTICE: see above */
 static uint16_t ssl_preset_suiteb_sig_algs[] = {
 
@@ -5207,38 +5206,25 @@ static uint16_t ssl_preset_suiteb_sig_algs[] = {
     // == MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_ECDSA, MBEDTLS_SSL_HASH_SHA384)
 #endif
 
-#if defined(MBEDTLS_X509_RSASSA_PSS_SUPPORT) && \
-    defined(MBEDTLS_MD_CAN_SHA256)
-    MBEDTLS_TLS1_3_SIG_RSA_PSS_RSAE_SHA256,
-#endif \
-    /* MBEDTLS_X509_RSASSA_PSS_SUPPORT && MBEDTLS_MD_CAN_SHA256*/
-
-#if defined(MBEDTLS_RSA_C) && defined(MBEDTLS_MD_CAN_SHA256)
-    MBEDTLS_TLS1_3_SIG_RSA_PKCS1_SHA256,
-#endif /* MBEDTLS_RSA_C && MBEDTLS_MD_CAN_SHA256*/
-
     MBEDTLS_TLS_SIG_NONE
 };
 
 /* NOTICE: see above */
 #if defined(MBEDTLS_SSL_PROTO_TLS1_2)
 static uint16_t ssl_tls12_preset_suiteb_sig_algs[] = {
+
 #if defined(MBEDTLS_MD_CAN_SHA256)
 #if defined(MBEDTLS_KEY_EXCHANGE_ECDSA_CERT_REQ_ALLOWED_ENABLED)
     MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_ECDSA, MBEDTLS_SSL_HASH_SHA256),
 #endif
-#if defined(MBEDTLS_RSA_C)
-    MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_RSA, MBEDTLS_SSL_HASH_SHA256),
-#endif
-#endif /* MBEDTLS_MD_CAN_SHA256*/
+#endif /* MBEDTLS_MD_CAN_SHA256 */
+
 #if defined(MBEDTLS_MD_CAN_SHA384)
 #if defined(MBEDTLS_KEY_EXCHANGE_ECDSA_CERT_REQ_ALLOWED_ENABLED)
     MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_ECDSA, MBEDTLS_SSL_HASH_SHA384),
 #endif
-#if defined(MBEDTLS_RSA_C)
-    MBEDTLS_SSL_TLS12_SIG_AND_HASH_ALG(MBEDTLS_SSL_SIG_RSA, MBEDTLS_SSL_HASH_SHA384),
-#endif
-#endif /* MBEDTLS_MD_CAN_SHA256*/
+#endif /* MBEDTLS_MD_CAN_SHA384 */
+
     MBEDTLS_TLS_SIG_NONE
 };
 #endif /* MBEDTLS_SSL_PROTO_TLS1_2 */