diff --git a/src/yuzu/main.cpp b/src/yuzu/main.cpp
index 524650144f..c55f81c2f1 100644
--- a/src/yuzu/main.cpp
+++ b/src/yuzu/main.cpp
@@ -2229,8 +2229,10 @@ void GMainWindow::OnGameListRemoveFile(u64 program_id, GameListRemoveTarget targ
     }
 
     switch (target) {
-    case GameListRemoveTarget::GlShaderCache:
     case GameListRemoveTarget::VkShaderCache:
+        RemoveVulkanDriverPipelineCache(program_id);
+        [[fallthrough]];
+    case GameListRemoveTarget::GlShaderCache:
         RemoveTransferableShaderCache(program_id, target);
         break;
     case GameListRemoveTarget::AllShaderCache:
@@ -2271,6 +2273,22 @@ void GMainWindow::RemoveTransferableShaderCache(u64 program_id, GameListRemoveTa
     }
 }
 
+void GMainWindow::RemoveVulkanDriverPipelineCache(u64 program_id) {
+    static constexpr std::string_view target_file_name = "vulkan_pipelines.bin";
+
+    const auto shader_cache_dir = Common::FS::GetYuzuPath(Common::FS::YuzuPath::ShaderDir);
+    const auto shader_cache_folder_path = shader_cache_dir / fmt::format("{:016x}", program_id);
+    const auto target_file = shader_cache_folder_path / target_file_name;
+
+    if (!Common::FS::Exists(target_file)) {
+        return;
+    }
+    if (!Common::FS::RemoveFile(target_file)) {
+        QMessageBox::warning(this, tr("Error Removing Vulkan Driver Pipeline Cache"),
+                             tr("Failed to remove the driver pipeline cache."));
+    }
+}
+
 void GMainWindow::RemoveAllTransferableShaderCaches(u64 program_id) {
     const auto shader_cache_dir = Common::FS::GetYuzuPath(Common::FS::YuzuPath::ShaderDir);
     const auto program_shader_cache_dir = shader_cache_dir / fmt::format("{:016x}", program_id);
diff --git a/src/yuzu/main.h b/src/yuzu/main.h
index db318485df..f25ce65a89 100644
--- a/src/yuzu/main.h
+++ b/src/yuzu/main.h
@@ -347,6 +347,7 @@ private:
     void RemoveUpdateContent(u64 program_id, InstalledEntryType type);
     void RemoveAddOnContent(u64 program_id, InstalledEntryType type);
     void RemoveTransferableShaderCache(u64 program_id, GameListRemoveTarget target);
+    void RemoveVulkanDriverPipelineCache(u64 program_id);
     void RemoveAllTransferableShaderCaches(u64 program_id);
     void RemoveCustomConfiguration(u64 program_id, const std::string& game_path);
     std::optional<u64> SelectRomFSDumpTarget(const FileSys::ContentProvider&, u64 program_id);