diff --git a/src/frontend/A32/decoder/thumb32.h b/src/frontend/A32/decoder/thumb32.h
index 18331827..09da4857 100644
--- a/src/frontend/A32/decoder/thumb32.h
+++ b/src/frontend/A32/decoder/thumb32.h
@@ -244,7 +244,7 @@ std::optional<std::reference_wrapper<const Thumb32Matcher<V>>> DecodeThumb32(u32
         INST(&V::thumb32_QADD16,         "QADD16",                   "111110101001nnnn1111dddd0001mmmm"),
         INST(&V::thumb32_QASX,           "QASX",                     "111110101010nnnn1111dddd0001mmmm"),
         INST(&V::thumb32_QSAX,           "QSAX",                     "111110101110nnnn1111dddd0001mmmm"),
-        //INST(&V::thumb32_QSUB16,         "QSUB16",                   "111110101101----1111----0001----"),
+        INST(&V::thumb32_QSUB16,         "QSUB16",                   "111110101101nnnn1111dddd0001mmmm"),
         //INST(&V::thumb32_QADD8,          "QADD8",                    "111110101000----1111----0001----"),
         //INST(&V::thumb32_QSUB8,          "QSUB8",                    "111110101100----1111----0001----"),
         //INST(&V::thumb32_SHADD16,        "SHADD16",                  "111110101001----1111----0010----"),
@@ -264,7 +264,7 @@ std::optional<std::reference_wrapper<const Thumb32Matcher<V>>> DecodeThumb32(u32
         INST(&V::thumb32_UQADD16,        "UQADD16",                  "111110101001nnnn1111dddd0101mmmm"),
         INST(&V::thumb32_UQASX,          "UQASX",                    "111110101010nnnn1111dddd0101mmmm"),
         INST(&V::thumb32_UQSAX,          "UQSAX",                    "111110101110nnnn1111dddd0101mmmm"),
-        //INST(&V::thumb32_UQSUB16,        "UQSUB16",                  "111110101101----1111----0101----"),
+        INST(&V::thumb32_UQSUB16,        "UQSUB16",                  "111110101101nnnn1111dddd0101mmmm"),
         //INST(&V::thumb32_UQADD8,         "UQADD8",                   "111110101000----1111----0101----"),
         //INST(&V::thumb32_UQSUB8,         "UQSUB8",                   "111110101100----1111----0101----"),
         //INST(&V::thumb32_UHADD16,        "UHADD16",                  "111110101001----1111----0110----"),
diff --git a/src/frontend/A32/translate/impl/thumb32_parallel.cpp b/src/frontend/A32/translate/impl/thumb32_parallel.cpp
index 9bd865ae..26373fad 100644
--- a/src/frontend/A32/translate/impl/thumb32_parallel.cpp
+++ b/src/frontend/A32/translate/impl/thumb32_parallel.cpp
@@ -233,6 +233,19 @@ bool ThumbTranslatorVisitor::thumb32_QSAX(Reg n, Reg d, Reg m) {
     return true;
 }
 
+bool ThumbTranslatorVisitor::thumb32_QSUB16(Reg n, Reg d, Reg m) {
+    if (d == Reg::PC || n == Reg::PC || m == Reg::PC) {
+        return UnpredictableInstruction();
+    }
+
+    const auto reg_m = ir.GetRegister(m);
+    const auto reg_n = ir.GetRegister(n);
+    const auto result = ir.PackedSaturatedSubS16(reg_n, reg_m);
+
+    ir.SetRegister(d, result);
+    return true;
+}
+
 bool ThumbTranslatorVisitor::thumb32_UQADD16(Reg n, Reg d, Reg m) {
     if (d == Reg::PC || n == Reg::PC || m == Reg::PC) {
         return UnpredictableInstruction();
@@ -284,4 +297,17 @@ bool ThumbTranslatorVisitor::thumb32_UQSAX(Reg n, Reg d, Reg m) {
     return true;
 }
 
+bool ThumbTranslatorVisitor::thumb32_UQSUB16(Reg n, Reg d, Reg m) {
+    if (d == Reg::PC || n == Reg::PC || m == Reg::PC) {
+        return UnpredictableInstruction();
+    }
+
+    const auto reg_m = ir.GetRegister(m);
+    const auto reg_n = ir.GetRegister(n);
+    const auto result = ir.PackedSaturatedSubU16(reg_n, reg_m);
+
+    ir.SetRegister(d, result);
+    return true;
+}
+
 } // namespace Dynarmic::A32
diff --git a/src/frontend/A32/translate/impl/translate_thumb.h b/src/frontend/A32/translate/impl/translate_thumb.h
index 16e1233e..6ef23c0d 100644
--- a/src/frontend/A32/translate/impl/translate_thumb.h
+++ b/src/frontend/A32/translate/impl/translate_thumb.h
@@ -145,9 +145,11 @@ struct ThumbTranslatorVisitor final {
     bool thumb32_QADD16(Reg n, Reg d, Reg m);
     bool thumb32_QASX(Reg n, Reg d, Reg m);
     bool thumb32_QSAX(Reg n, Reg d, Reg m);
+    bool thumb32_QSUB16(Reg n, Reg d, Reg m);
     bool thumb32_UQADD16(Reg n, Reg d, Reg m);
     bool thumb32_UQASX(Reg n, Reg d, Reg m);
     bool thumb32_UQSAX(Reg n, Reg d, Reg m);
+    bool thumb32_UQSUB16(Reg n, Reg d, Reg m);
 };
 
 } // namespace Dynarmic::A32
diff --git a/tests/A32/fuzz_thumb.cpp b/tests/A32/fuzz_thumb.cpp
index 9d9fda33..700193f9 100644
--- a/tests/A32/fuzz_thumb.cpp
+++ b/tests/A32/fuzz_thumb.cpp
@@ -390,6 +390,8 @@ TEST_CASE("Fuzz Thumb32 instructions set", "[JitX64][Thumb][Thumb32]") {
                      three_reg_not_r15),
         ThumbInstGen("111110101000nnnn1111dddd1010mmmm", // QSUB
                      three_reg_not_r15),
+        ThumbInstGen("111110101101nnnn1111dddd0001mmmm", // QSUB16
+                     three_reg_not_r15),
         ThumbInstGen("111110101001nnnn1111dddd1010mmmm", // RBIT
                      [](u32 inst) {
                          const auto d = Common::Bits<8, 11>(inst);
@@ -444,6 +446,8 @@ TEST_CASE("Fuzz Thumb32 instructions set", "[JitX64][Thumb][Thumb32]") {
                      three_reg_not_r15),
         ThumbInstGen("111110101110nnnn1111dddd0101mmmm", // UQSAX
                      three_reg_not_r15),
+        ThumbInstGen("111110101101nnnn1111dddd0101mmmm", // UQSUB16
+                     three_reg_not_r15),
         ThumbInstGen("111110101110nnnn1111dddd0100mmmm", // USAX
                      three_reg_not_r15),
         ThumbInstGen("111110101100nnnn1111dddd0100mmmm", // USUB8