diff --git a/pkgs/development/python-modules/lmfit/default.nix b/pkgs/development/python-modules/lmfit/default.nix
new file mode 100644
index 000000000000..bed095186ec9
--- /dev/null
+++ b/pkgs/development/python-modules/lmfit/default.nix
@@ -0,0 +1,61 @@
+{ lib,
+  buildPythonPackage,
+  fetchPypi,
+  setuptools,
+  setuptools-scm,
+  asteval,
+  numpy,
+  scipy,
+  uncertainties,
+  pytestCheckHook,
+  pandas,
+  matplotlib,
+}:
+
+buildPythonPackage rec {
+  pname = "lmfit";
+  version = "1.2.1";
+
+  format = "pyproject";
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-AM71vRRb+BtzYwt4kmrySyTxgFQh5iEcpYVYiqfMQVs=";
+  };
+
+  postPatch = ''
+    substituteInPlace setup.cfg --replace "--cov=lmfit --cov-report html" ""
+  '';
+
+  nativeBuildInputs = [
+    setuptools
+    setuptools-scm
+  ];
+
+  propagatedBuildInputs = [
+    asteval
+    numpy
+    scipy
+    uncertainties
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+    pandas
+    matplotlib
+  ];
+
+  disabledTests = [
+    # https://github.com/lmfit/lmfit-py/issues/878
+    "test_emcee_multiprocessing"
+    "test_explicit_independent_vars"
+    "test_result_eval_custom_x"
+  ];
+
+  meta = with lib; {
+    description = "Least-Squares Minimization with Bounds and Constraints";
+    homepage = "https://lmfit-py.readthedocs.io/";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ nomeata ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 1a6d936c7b4f..f4c2e710c5d6 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5777,6 +5777,8 @@ self: super: with self; {
     inherit (pkgs) lmdb;
   };
 
+  lmfit = callPackage ../development/python-modules/lmfit { };
+
   lml = callPackage ../development/python-modules/lml { };
 
   lmnotify = callPackage ../development/python-modules/lmnotify { };