diff --git a/pkgs/applications/science/biology/truvari/default.nix b/pkgs/applications/science/biology/truvari/default.nix
index fffeca2c740c..31c1fc50ee3e 100644
--- a/pkgs/applications/science/biology/truvari/default.nix
+++ b/pkgs/applications/science/biology/truvari/default.nix
@@ -5,15 +5,20 @@
 
 python3Packages.buildPythonApplication rec {
   pname = "truvari";
-  version = "2.0.2";
+  version = "2.1.1";
 
   src = fetchFromGitHub {
     owner = "spiralgenetics";
     repo = "truvari";
     rev = "v${version}";
-    sha256 = "0lp1wnldjv92k4ncga1h0icb0dpjsrx427vggg40x04a7kp9lwx0";
+    sha256 = "14nsdbj063qm175xxixs34cihvsiskc9gym8pg7gbwsh13k5a00h";
   };
 
+  postPatch = ''
+    substituteInPlace setup.py \
+      --replace 'python-Levenshtein==0.12.1' 'python-Levenshtein>=0.12.1'
+  '';
+
   propagatedBuildInputs = with python3Packages; [
     pyvcf
     python-Levenshtein