diff --git a/pkgs/development/libraries/zydis/default.nix b/pkgs/development/libraries/zydis/default.nix
index 7009123a4528..901d32b39595 100644
--- a/pkgs/development/libraries/zydis/default.nix
+++ b/pkgs/development/libraries/zydis/default.nix
@@ -6,14 +6,14 @@
 
 stdenv.mkDerivation rec {
   pname = "zydis";
-  version = "3.2.1";
+  version = "4.0.0";
 
   src = fetchFromGitHub {
     owner = "zyantific";
     repo = "zydis";
     rev = "v${version}";
     fetchSubmodules = true;
-    sha256 = "sha256-FB7hGQ9vI3ZE376iROEpdtZm91IiccBhtAFa94JgnUY=";
+    sha256 = "sha256-WSBi8HUVj/JR0/0pBoEaUKD0kOk41gSW5ZW74fn8b4k=";
   };
 
   nativeBuildInputs = [