diff --git a/pkgs/development/tools/build-managers/cmake/default.nix b/pkgs/development/tools/build-managers/cmake/default.nix
index d14605074660..b04eac35b05c 100644
--- a/pkgs/development/tools/build-managers/cmake/default.nix
+++ b/pkgs/development/tools/build-managers/cmake/default.nix
@@ -7,19 +7,14 @@
 , useSharedLibraries ? (!isBootstrap && !stdenv.isCygwin)
 , useOpenSSL ? !isBootstrap, openssl
 , useNcurses ? false, ncurses
-, useQt4 ? false, qt4
 , withQt5 ? false, qtbase
 }:
 
-assert withQt5 -> useQt4 == false;
-assert useQt4 -> withQt5 == false;
-
 stdenv.mkDerivation (rec {
   pname = "cmake"
           + lib.optionalString isBootstrap "-boot"
           + lib.optionalString useNcurses "-cursesUI"
-          + lib.optionalString withQt5 "-qt5UI"
-          + lib.optionalString useQt4 "-qt4UI";
+          + lib.optionalString withQt5 "-qt5UI";
   version = "3.19.7";
 
   src = fetchurl {
@@ -53,7 +48,6 @@ stdenv.mkDerivation (rec {
     ++ lib.optionals useSharedLibraries [ bzip2 curlMinimal expat libarchive xz zlib libuv rhash ]
     ++ lib.optional useOpenSSL openssl
     ++ lib.optional useNcurses ncurses
-    ++ lib.optional useQt4 qt4
     ++ lib.optional withQt5 qtbase;
 
   propagatedBuildInputs = lib.optional stdenv.isDarwin ps;
@@ -73,7 +67,7 @@ stdenv.mkDerivation (rec {
   configureFlags = [
     "--docdir=share/doc/${pname}${version}"
   ] ++ (if useSharedLibraries then [ "--no-system-jsoncpp" "--system-libs" ] else [ "--no-system-libs" ]) # FIXME: cleanup
-    ++ lib.optional (useQt4 || withQt5) "--qt-gui"
+    ++ lib.optional withQt5 "--qt-gui"
     # Workaround https://gitlab.kitware.com/cmake/cmake/-/issues/20568
     ++ lib.optionals stdenv.hostPlatform.is32bit [
       "CFLAGS=-D_FILE_OFFSET_BITS=64"
@@ -124,7 +118,7 @@ stdenv.mkDerivation (rec {
       configuration files, and generate native makefiles and workspaces that
       can be used in the compiler environment of your choice.
     '';
-    platforms = if useQt4 then qt4.meta.platforms else platforms.all;
+    platforms = platforms.all;
     maintainers = with maintainers; [ ttuegel lnl7 ];
     license = licenses.bsd3;
   };
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 779f97ea4680..1889370cc31f 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -115,6 +115,7 @@ mapAliases ({
   clangAnalyzer = clang-analyzer;  # added 2015-02-20
   clawsMail = claws-mail; # added 2016-04-29
   clutter_gtk = clutter-gtk; # added 2018-02-25
+  cmakeWithQt4Gui = throw "cmakeWithQt4Gui has been removed in favor of cmakeWithGui (Qt 5)"; # added 2021-05
   codimd = hedgedoc; # added 2020-11-29
   compton = picom; # added 2019-12-02
   compton-git = compton; # added 2019-05-20
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 8f44545efcc8..a3ef9e0df2a6 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -12871,7 +12871,6 @@ in
   cmakeCurses = cmake.override { useNcurses = true; };
 
   cmakeWithGui = cmakeCurses.override { withQt5 = true; };
-  cmakeWithQt4Gui = cmakeCurses.override { useQt4 = true; };
 
   cmake-format = python3Packages.callPackage ../development/tools/cmake-format { };