diff --git a/pkgs/applications/blockchains/lighthouse/default.nix b/pkgs/applications/blockchains/lighthouse/default.nix
index 20792dd8fd95..44cbb147bd20 100644
--- a/pkgs/applications/blockchains/lighthouse/default.nix
+++ b/pkgs/applications/blockchains/lighthouse/default.nix
@@ -14,6 +14,7 @@
 , rustPlatform
 , Security
 , sqlite
+, rust-jemalloc-sys
 , stdenv
 , SystemConfiguration
 , testers
@@ -70,6 +71,7 @@ rustPlatform.buildRustPackage rec {
 
   buildInputs = [
     sqlite
+    rust-jemalloc-sys
   ] ++ lib.optionals stdenv.isDarwin [
     CoreFoundation
     Security
diff --git a/pkgs/applications/blockchains/polkadot/default.nix b/pkgs/applications/blockchains/polkadot/default.nix
index 1ed5d9819110..4be874ef5ce1 100644
--- a/pkgs/applications/blockchains/polkadot/default.nix
+++ b/pkgs/applications/blockchains/polkadot/default.nix
@@ -2,6 +2,7 @@
 , lib
 , protobuf
 , rocksdb
+, rust-jemalloc-sys-unprefixed
 , rustPlatform
 , rustc-wasm32
 , stdenv
@@ -60,7 +61,9 @@ rustPlatform.buildRustPackage rec {
     rustc-wasm32.llvmPackages.lld
   ];
 
-  buildInputs = lib.optionals stdenv.isDarwin [ Security SystemConfiguration ];
+  buildInputs = [
+    rust-jemalloc-sys-unprefixed
+  ] ++ lib.optionals stdenv.isDarwin [ Security SystemConfiguration ];
 
   # NOTE: we need to force lld otherwise rust-lld is not found for wasm32 target
   CARGO_TARGET_WASM32_UNKNOWN_UNKNOWN_LINKER = "lld";
diff --git a/pkgs/applications/office/activitywatch/default.nix b/pkgs/applications/office/activitywatch/default.nix
index 04d58e74dadd..4187da1bfabb 100644
--- a/pkgs/applications/office/activitywatch/default.nix
+++ b/pkgs/applications/office/activitywatch/default.nix
@@ -5,6 +5,7 @@
 , pkg-config
 , perl
 , openssl
+, rust-jemalloc-sys
 , python3
 , wrapQtAppsHook
 , qtbase
@@ -173,6 +174,7 @@ rec {
 
     buildInputs = [
       openssl
+      rust-jemalloc-sys
     ];
 
     postFixup = ''
diff --git a/pkgs/development/python-modules/polars/default.nix b/pkgs/development/python-modules/polars/default.nix
index b070ae37978f..ccd6f2b79ba9 100644
--- a/pkgs/development/python-modules/polars/default.nix
+++ b/pkgs/development/python-modules/polars/default.nix
@@ -6,6 +6,7 @@
 , libiconv
 , fetchFromGitHub
 , typing-extensions
+, rust-jemalloc-sys
 , darwin
 }:
 let
@@ -49,7 +50,9 @@ buildPythonPackage {
 
   nativeBuildInputs = with rustPlatform; [ cargoSetupHook maturinBuildHook ];
 
-  buildInputs = lib.optionals stdenv.isDarwin [
+  buildInputs = [
+    rust-jemalloc-sys
+  ] ++ lib.optionals stdenv.isDarwin [
     libiconv
     darwin.apple_sdk.frameworks.Security
   ];
diff --git a/pkgs/development/tools/ruff/default.nix b/pkgs/development/tools/ruff/default.nix
index b7c5ab87a644..8b42bfbe85c5 100644
--- a/pkgs/development/tools/ruff/default.nix
+++ b/pkgs/development/tools/ruff/default.nix
@@ -4,6 +4,7 @@
 , installShellFiles
 , stdenv
 , darwin
+, rust-jemalloc-sys
   # tests
 , ruff-lsp
 }:
@@ -31,19 +32,15 @@ rustPlatform.buildRustPackage rec {
     installShellFiles
   ];
 
-  buildInputs = lib.optionals stdenv.isDarwin [
+  buildInputs = [
+    rust-jemalloc-sys
+  ] ++ lib.optionals stdenv.isDarwin [
     darwin.apple_sdk.frameworks.CoreServices
   ];
 
   cargoBuildFlags = [ "--package=ruff_cli" ];
   cargoTestFlags = cargoBuildFlags;
 
-  preBuild = lib.optionalString (stdenv.isDarwin && stdenv.isx86_64) ''
-    # See https://github.com/jemalloc/jemalloc/issues/1997
-    # Using a value of 48 should work on both emulated and native x86_64-darwin.
-    export JEMALLOC_SYS_WITH_LG_VADDR=48
-  '';
-
   # tests expect no colors
   preCheck = ''
     export NO_COLOR=1
diff --git a/pkgs/servers/kanidm/default.nix b/pkgs/servers/kanidm/default.nix
index e6c49b846f4b..65450e0e3eb9 100644
--- a/pkgs/servers/kanidm/default.nix
+++ b/pkgs/servers/kanidm/default.nix
@@ -11,6 +11,7 @@
 , sqlite
 , pam
 , bashInteractive
+, rust-jemalloc-sys
 }:
 
 let
@@ -59,6 +60,7 @@ rustPlatform.buildRustPackage rec {
     openssl
     sqlite
     pam
+    rust-jemalloc-sys
   ];
 
   # The UI needs to be in place before the tests are run.
diff --git a/pkgs/servers/matrix-conduit/default.nix b/pkgs/servers/matrix-conduit/default.nix
index 6cb8f16d203c..cc162e6373d6 100644
--- a/pkgs/servers/matrix-conduit/default.nix
+++ b/pkgs/servers/matrix-conduit/default.nix
@@ -7,6 +7,7 @@
 , darwin
 , nixosTests
 , rocksdb
+, rust-jemalloc-sys
 }:
 
 rustPlatform.buildRustPackage rec {
@@ -42,7 +43,10 @@ rustPlatform.buildRustPackage rec {
     pkg-config
   ];
 
-  buildInputs = [ sqlite ] ++ lib.optionals stdenv.isDarwin [
+  buildInputs = [
+    sqlite
+    rust-jemalloc-sys
+  ] ++ lib.optionals stdenv.isDarwin [
     darwin.apple_sdk.frameworks.Security
   ];
 
diff --git a/pkgs/servers/search/qdrant/default.nix b/pkgs/servers/search/qdrant/default.nix
index 005514819820..6d70b5e4b3da 100644
--- a/pkgs/servers/search/qdrant/default.nix
+++ b/pkgs/servers/search/qdrant/default.nix
@@ -5,6 +5,7 @@
 , stdenv
 , pkg-config
 , openssl
+, rust-jemalloc-sys
 , nix-update-script
 , Security
 }:
@@ -32,7 +33,10 @@ rustPlatform.buildRustPackage rec {
   # Needed to get openssl-sys to use pkg-config.
   OPENSSL_NO_VENDOR = 1;
 
-  buildInputs = [ openssl ] ++ lib.optionals stdenv.isDarwin [ Security ];
+  buildInputs = [
+    openssl
+    rust-jemalloc-sys
+  ] ++ lib.optionals stdenv.isDarwin [ Security ];
 
   nativeBuildInputs = [ protobuf rustPlatform.bindgenHook pkg-config ];
 
diff --git a/pkgs/servers/search/quickwit/default.nix b/pkgs/servers/search/quickwit/default.nix
index 9fdcbef3e712..f4d75be434ec 100644
--- a/pkgs/servers/search/quickwit/default.nix
+++ b/pkgs/servers/search/quickwit/default.nix
@@ -4,6 +4,7 @@
 , rustPlatform
 , nix-update-script
 , protobuf
+, rust-jemalloc-sys
 , Security
 }:
 
@@ -32,7 +33,9 @@ rustPlatform.buildRustPackage rec {
 
   sourceRoot = "${src.name}/quickwit";
 
-  buildInputs = lib.optionals stdenv.isDarwin [ Security ];
+  buildInputs = [
+    rust-jemalloc-sys
+  ] ++ lib.optionals stdenv.isDarwin [ Security ];
 
   cargoLock = {
     lockFile = ./Cargo.lock;
diff --git a/pkgs/tools/misc/fd/default.nix b/pkgs/tools/misc/fd/default.nix
index 0f78b752de00..23e00e00363c 100644
--- a/pkgs/tools/misc/fd/default.nix
+++ b/pkgs/tools/misc/fd/default.nix
@@ -1,4 +1,4 @@
-{ lib, rustPlatform, fetchFromGitHub, installShellFiles, testers, fd }:
+{ lib, rustPlatform, fetchFromGitHub, installShellFiles, rust-jemalloc-sys, testers, fd }:
 
 rustPlatform.buildRustPackage rec {
   pname = "fd";
@@ -15,6 +15,8 @@ rustPlatform.buildRustPackage rec {
 
   nativeBuildInputs = [ installShellFiles ];
 
+  buildInputs = [ rust-jemalloc-sys ];
+
   # skip flaky test
   checkFlags = [
     "--skip=test_owner_current_group"
diff --git a/pkgs/tools/misc/turbo/default.nix b/pkgs/tools/misc/turbo/default.nix
index f3fcd8cd0f30..c887fdc131c2 100644
--- a/pkgs/tools/misc/turbo/default.nix
+++ b/pkgs/tools/misc/turbo/default.nix
@@ -12,6 +12,7 @@
 , openssl
 , extra-cmake-modules
 , fontconfig
+, rust-jemalloc-sys
 , testers
 , turbo
 , nix-update-script
@@ -149,6 +150,7 @@ rustPlatform.buildRustPackage {
   buildInputs = [
     openssl
     fontconfig
+    rust-jemalloc-sys
   ] ++ lib.optionals stdenv.isDarwin [
       IOKit
       CoreServices
diff --git a/pkgs/tools/misc/vector/default.nix b/pkgs/tools/misc/vector/default.nix
index b1fd29e74673..c50d136d051e 100644
--- a/pkgs/tools/misc/vector/default.nix
+++ b/pkgs/tools/misc/vector/default.nix
@@ -8,6 +8,7 @@
 , rdkafka
 , oniguruma
 , zstd
+, rust-jemalloc-sys
 , Security
 , libiconv
 , coreutils
@@ -59,7 +60,7 @@ rustPlatform.buildRustPackage {
     };
   };
   nativeBuildInputs = [ pkg-config cmake perl git rustPlatform.bindgenHook ];
-  buildInputs = [ oniguruma openssl protobuf rdkafka zstd ]
+  buildInputs = [ oniguruma openssl protobuf rdkafka zstd rust-jemalloc-sys ]
     ++ lib.optionals stdenv.isDarwin [ Security libiconv coreutils CoreServices ];
 
   # needed for internal protobuf c wrapper library