diff --git a/pkgs/development/python-modules/pycrypto/default.nix b/pkgs/development/python-modules/pycrypto/default.nix
index 59bd9affef67..4faaf20d29c3 100644
--- a/pkgs/development/python-modules/pycrypto/default.nix
+++ b/pkgs/development/python-modules/pycrypto/default.nix
@@ -9,6 +9,11 @@ buildPythonPackage rec {
     sha256 = "0g0ayql5b9mkjam8hym6zyg6bv77lbh66rv1fyvgqb17kfc1xkpj";
   };
 
+  preConfigure = ''
+    sed -i 's,/usr/include,/no-such-dir,' configure
+    sed -i "s!,'/usr/include/'!!" setup.py
+  '';
+
   buildInputs = stdenv.lib.optional (!python.isPypy or false) gmp; # optional for pypy
 
   doCheck = !(python.isPypy or stdenv.isDarwin); # error: AF_UNIX path too long