diff --git a/pkgs/development/libraries/openssl/default.nix b/pkgs/development/libraries/openssl/default.nix
index 33ddbf7018c5..e364cc3dd76e 100644
--- a/pkgs/development/libraries/openssl/default.nix
+++ b/pkgs/development/libraries/openssl/default.nix
@@ -69,6 +69,12 @@ let
         x86_64-linux = "./Configure linux-x86_64";
         x86_64-solaris = "./Configure solaris64-x86_64-gcc";
         riscv64-linux = "./Configure linux64-riscv64";
+        mips64el-linux =
+          if stdenv.hostPlatform.isMips64n64
+          then "./Configure linux64-mips64"
+          else if stdenv.hostPlatform.isMips64n32
+          then "./Configure linux-mips64"
+          else throw "unsupported ABI for ${stdenv.hostPlatform.system}";
       }.${stdenv.hostPlatform.system} or (
         if stdenv.hostPlatform == stdenv.buildPlatform
           then "./config"