diff --git a/pkgs/development/python-modules/pylibjpeg-libjpeg/default.nix b/pkgs/development/python-modules/pylibjpeg-libjpeg/default.nix
index a9ffc663fcaf..3872fa6b2417 100644
--- a/pkgs/development/python-modules/pylibjpeg-libjpeg/default.nix
+++ b/pkgs/development/python-modules/pylibjpeg-libjpeg/default.nix
@@ -3,14 +3,16 @@
 , fetchFromGitHub
 , pythonOlder
 , pytestCheckHook
-, cython
+, cython_3
+, poetry-core
+, setuptools
 , numpy
 }:
 
 buildPythonPackage rec {
   pname = "pylibjpeg-libjpeg";
-  version = "1.3.4";
-  format = "setuptools";
+  version = "2.02";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
@@ -18,12 +20,14 @@ buildPythonPackage rec {
     owner = "pydicom";
     repo = pname;
     rev = "refs/tags/v${version}";
-    hash = "sha256-VmqeoMU8riLpWyC+yKqq56TkruxOie6pjbg+ozivpBk=";
+    hash = "sha256-mGwku19Xe605fF3UU59712rYp+s/pP79lBRl79fhhTI=";
     fetchSubmodules = true;
   };
 
   nativeBuildInputs = [
-    cython
+    cython_3
+    poetry-core
+    setuptools
   ];
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/python-modules/pylibjpeg/default.nix b/pkgs/development/python-modules/pylibjpeg/default.nix
index 65055d94280c..134b0ebdb993 100644
--- a/pkgs/development/python-modules/pylibjpeg/default.nix
+++ b/pkgs/development/python-modules/pylibjpeg/default.nix
@@ -4,6 +4,7 @@
 , fetchFromGitHub
 , pythonOlder
 , pytestCheckHook
+, flit-core
 , setuptools
 , numpy
 , pydicom
@@ -31,7 +32,7 @@ in
 
 buildPythonPackage rec {
   pname = "pylibjpeg";
-  version = "1.4.0";
+  version = "2.0.0";
   pyproject = true;
 
   disabled = pythonOlder "3.7";
@@ -40,10 +41,10 @@ buildPythonPackage rec {
     owner = "pydicom";
     repo = "pylibjpeg";
     rev = "refs/tags/v${version}";
-    hash = "sha256-Px1DyYDkKAUdYo+ZxZ1w7TkPzWN++styiFl02iQOvyQ=";
+    hash = "sha256-qGtrphsBBVieGS/8rdymbsjLMU/QEd7zFNAANN8bD+k=";
   };
 
-  nativeBuildInputs = [ setuptools ];
+  nativeBuildInputs = [ flit-core ];
 
   propagatedBuildInputs = [ numpy ];