diff --git a/pkgs/applications/audio/in-formant/0001-Avoid-using-vendored-dependencies-we-have-in-nixpkgs.patch b/pkgs/applications/audio/in-formant/0001-Avoid-using-vendored-dependencies-we-have-in-nixpkgs.patch
new file mode 100644
index 000000000000..b45b3218f358
--- /dev/null
+++ b/pkgs/applications/audio/in-formant/0001-Avoid-using-vendored-dependencies-we-have-in-nixpkgs.patch
@@ -0,0 +1,47 @@
+From 42eda1afc1cfb0506b02baae894fb32f7e21755d Mon Sep 17 00:00:00 2001
+From: ckie <git-525ff67@ckie.dev>
+Date: Fri, 10 Mar 2023 04:39:38 +0200
+Subject: [PATCH] Avoid using vendored dependencies we have in nixpkgs
+
+---
+ CMakeLists.txt | 12 ++++--------
+ 1 file changed, 4 insertions(+), 8 deletions(-)
+
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index 136e7b0..5416da1 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -246,8 +246,6 @@ qt6_add_resources(RESOURCES_OBJ resources/qml.qrc)
+ qt6_add_big_resources(RESOURCES_OBJ resources/other.qrc)
+ set_property(SOURCE "${RESOURCES_OBJ}" PROPERTY SKIP_AUTOMOC ON)
+ 
+-set(ARMADILLO_INCLUDE_DIR external/armadillo/include)
+-set(TOMLPP_INCLUDE_DIR external/tomlplusplus/include)
+ 
+ ### SEARCH AUDIO MODULES 
+ 
+@@ -334,17 +332,15 @@ target_include_directories(in-formant SYSTEM PRIVATE ${ARMADILLO_INCLUDE_DIR} ${
+ target_link_libraries(in-formant PRIVATE Eigen3::Eigen ${FFTW_LIBRARIES} Qt6::Charts Qt6::Quick Qt6::QuickControls2 Qt6::QuickTemplates2 Qt6::Qml Qt6::Widgets Qt6::OpenGL Qt6::Gui Qt6::Core)
+ target_link_directories(in-formant PRIVATE ${FFTW_LIBRARY_DIRS})
+ 
+-set(BUILD_SHARED_LIBS TRUE)
+-add_subdirectory(external/freetype EXCLUDE_FROM_ALL)
++find_package(Freetype)
+ target_link_libraries(in-formant PRIVATE freetype)
+-set(BUILD_SHARED_LIBS)
+ 
+ add_subdirectory(external/rpmalloc EXCLUDE_FROM_ALL)
+ target_link_libraries(in-formant PRIVATE rpcxx_only)
+ 
+-add_subdirectory(external/libsamplerate)
+-target_link_libraries(in-formant PRIVATE lsr)
+-target_include_directories(in-formant PRIVATE external/libsamplerate/src)
++
++find_library(LIBSAMPLERATE_LIBRARY NAMES samplerate libsamplerate-0 samplerate-0)
++target_link_libraries(in-formant PRIVATE ${LIBSAMPLERATE_LIBRARY})
+ 
+ target_compile_definitions(in-formant PRIVATE
+     -DINFORMANT_VERSION=${CUR_VERSION} -DARMA_DONT_USE_WRAPPER
+-- 
+2.39.0
+
diff --git a/pkgs/applications/audio/in-formant/default.nix b/pkgs/applications/audio/in-formant/default.nix
index 5fb36b034506..6801e3641852 100644
--- a/pkgs/applications/audio/in-formant/default.nix
+++ b/pkgs/applications/audio/in-formant/default.nix
@@ -1,33 +1,56 @@
-{ stdenv, cmake, lib, fetchFromGitHub, qt5, fftw, libtorch-bin, portaudio, eigen
-, xorg, pkg-config, autoPatchelfHook, soxr
+{ stdenv
+, cmake
+, lib
+, fetchFromGitHub
+, wrapQtAppsHook
+, qtbase
+, qtcharts
+, fftw
+, libtorch-bin
+, portaudio
+, eigen
+, xorg
+, pkg-config
+, autoPatchelfHook
+, soxr
+, freetype
+, libsamplerate
+, armadillo
+, tomlplusplus
 }:
 
 stdenv.mkDerivation rec {
   pname = "in-formant";
-  version = "2021-06-30";
+  version = "unstable-2022-09-15";
 
-  # no Qt6 yet, so we're stuck in the last Qt5-supporting commit: https://github.com/NixOS/nixpkgs/issues/108008
   src = fetchFromGitHub {
     owner = "in-formant";
     repo = "in-formant";
-    rev = "e28e628cf5ff0949a7b046d220cc884f6035f31a";
-    sha256 = "sha256-YvtV0wGUNmI/+GGxrIfTk/l8tqUsWgc/LAI17X+AWGI=";
+    rev = "e0606feecff70f0fd4226ff8f116e46817dd7462";
+    hash = "sha256-/4eKny9M2e8Lb9LOiKBj9QLE00CAaD+2ZAwn48lnvKQ=";
     fetchSubmodules = true;
   };
 
-  nativeBuildInputs = [ cmake pkg-config qt5.wrapQtAppsHook autoPatchelfHook ];
+  patches = [
+    # Ignore the freetype sources bundled as a submodule:
+    # /nix/store/…-harfbuzz-7.0.0/lib/libharfbuzz.so.0: undefined reference to `FT_Get_Transform'
+    ./0001-Avoid-using-vendored-dependencies-we-have-in-nixpkgs.patch
+  ];
+
+  nativeBuildInputs = [ cmake pkg-config wrapQtAppsHook autoPatchelfHook ];
 
   buildInputs = [
-    qt5.qtbase
-    qt5.qtquickcontrols
-    qt5.qtquickcontrols2
-    qt5.qtcharts
+    qtbase
+    qtcharts
     fftw
     libtorch-bin
     portaudio
     eigen
     xorg.libxcb
     soxr
+    libsamplerate
+    armadillo
+    tomlplusplus
   ];
 
   installPhase = ''
@@ -35,14 +58,12 @@ stdenv.mkDerivation rec {
     cp in-formant $out/bin
   '';
 
-  # RPATH of binary /nix/store/.../bin/... contains a forbidden reference to /build/
-  cmakeFlags = [ "-DCMAKE_SKIP_BUILD_RPATH=ON" ];
-
   meta = with lib; {
     description = "A real-time pitch and formant tracking software";
     homepage = "https://github.com/in-formant/in-formant";
     license = licenses.asl20;
-    platforms = platforms.linux;
+    # currently broken on i686-linux and aarch64-linux due to other nixpkgs dependencies
+    platforms = [ "x86_64-linux" ];
     maintainers = with maintainers; [ ckie ];
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index dbca18144b4e..0f4f660cb084 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -8626,7 +8626,7 @@ with pkgs;
 
   imgurbash2 = callPackage ../tools/graphics/imgurbash2 { };
 
-  in-formant = callPackage ../applications/audio/in-formant { };
+  in-formant = qt6Packages.callPackage ../applications/audio/in-formant { };
 
   inadyn = callPackage ../tools/networking/inadyn { };