diff --git a/pkgs/development/python-modules/ctranslate2/default.nix b/pkgs/development/python-modules/ctranslate2/default.nix
new file mode 100644
index 000000000000..4cbf0ecd7124
--- /dev/null
+++ b/pkgs/development/python-modules/ctranslate2/default.nix
@@ -0,0 +1,84 @@
+{ lib
+, buildPythonPackage
+
+# build-system
+, pybind11
+, setuptools
+
+# dependencies
+, ctranslate2-cpp
+, numpy
+, pyyaml
+
+# tests
+, pytestCheckHook
+, tensorflow
+, torch
+, transformers
+, wurlitzer
+}:
+
+buildPythonPackage rec {
+  inherit (ctranslate2-cpp) pname version src;
+  format = "setuptools";
+
+  # https://github.com/OpenNMT/CTranslate2/tree/master/python
+  sourceRoot = "source/python";
+
+  nativeBuildInputs = [
+    pybind11
+    setuptools
+  ];
+
+  buildInputs = [
+    ctranslate2-cpp
+  ];
+
+  propagatedBuildInputs = [
+    numpy
+    pyyaml
+  ];
+
+  pythonImportsCheck = [
+    # https://opennmt.net/CTranslate2/python/overview.html
+    "ctranslate2"
+    "ctranslate2.converters"
+    "ctranslate2.models"
+    "ctranslate2.specs"
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+    tensorflow
+    torch
+    transformers
+    wurlitzer
+  ];
+
+  preCheck = ''
+    # run tests against build result, not sources
+    rm -rf ctranslate2
+
+    export HOME=$TMPDIR
+  '';
+
+  disabledTests = [
+    # AssertionError: assert 'int8' in {'float32'}
+    "test_get_supported_compute_types"
+  ];
+
+  disabledTestPaths = [
+    # TODO: ModuleNotFoundError: No module named 'opennmt'
+    "tests/test_opennmt_tf.py"
+    # OSError: We couldn't connect to 'https://huggingface.co' to load this file
+    "tests/test_transformers.py"
+  ];
+
+  meta = with lib; {
+    description = "Fast inference engine for Transformer models";
+    homepage = "https://github.com/OpenNMT/CTranslate2";
+    changelog = "https://github.com/OpenNMT/CTranslate2/blob/${src.rev}/CHANGELOG.md";
+    license = licenses.mit;
+    maintainers = with maintainers; [ hexa ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b9051f34031d..36a081dd6f0a 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -2218,6 +2218,10 @@ self: super: with self; {
 
   ctap-keyring-device = callPackage ../development/python-modules/ctap-keyring-device { };
 
+  ctranslate2 = callPackage ../development/python-modules/ctranslate2 {
+    ctranslate2-cpp = pkgs.ctranslate2;
+  };
+
   cu2qu = callPackage ../development/python-modules/cu2qu { };
 
   cucumber-tag-expressions = callPackage ../development/python-modules/cucumber-tag-expressions { };