diff --git a/pkgs/development/libraries/libewf/default.nix b/pkgs/development/libraries/libewf/default.nix
index 101f8f16a3f4..dffacc7d276c 100644
--- a/pkgs/development/libraries/libewf/default.nix
+++ b/pkgs/development/libraries/libewf/default.nix
@@ -13,6 +13,11 @@ stdenv.mkDerivation rec {
   buildInputs = [ zlib openssl libuuid ]
     ++ lib.optionals stdenv.isDarwin [ bzip2 ];
 
+  # cannot run test program while cross compiling
+  configureFlags = lib.optionals (!stdenv.buildPlatform.canExecute stdenv.hostPlatform) [
+    "ac_cv_openssl_xts_duplicate_keys=yes"
+  ];
+
   meta = {
     description = "Library for support of the Expert Witness Compression Format";
     homepage = "https://sourceforge.net/projects/libewf/";