diff --git a/pkgs/development/tools/misc/ccache/default.nix b/pkgs/development/tools/misc/ccache/default.nix
index 0cf98d651c5b..642a1cf4ebfe 100644
--- a/pkgs/development/tools/misc/ccache/default.nix
+++ b/pkgs/development/tools/misc/ccache/default.nix
@@ -13,19 +13,29 @@
 
 let ccache = stdenv.mkDerivation rec {
   pname = "ccache";
-  version = "4.2";
+  version = "4.2.1";
 
   src = fetchFromGitHub {
     owner = pname;
     repo = pname;
     rev = "v${version}";
-    sha256 = "1lr9804xyzbs72f9jbbzy1fjqxwrwpb4rp431wqialvms4251d8f";
+    hash = "sha256-AmgJpW7AGCSggbHp1fLO5yhXS9LIm7O77nQdDERJYAA=";
   };
 
-  patches = lib.optional stdenv.isDarwin (substituteAll {
-    src = ./force-objdump-on-darwin.patch;
-    objdump = "${binutils.bintools}/bin/objdump";
-  });
+  patches = [
+    # test/run use compgen to get environment variable names, but
+    # compgen isn't available in non-interactive bash.
+    ./env-instead-of-compgen.patch
+
+    # When building for Darwin, test/run uses dwarfdump, whereas on
+    # Linux it uses objdump. We don't have dwarfdump packaged for
+    # Darwin, so this patch updates the test to also use objdump on
+    # Darwin.
+    (substituteAll {
+      src = ./force-objdump-on-darwin.patch;
+      objdump = "${binutils.bintools}/bin/objdump";
+    })
+  ];
 
   nativeBuildInputs = [ asciidoc cmake perl ];
 
@@ -38,7 +48,7 @@ let ccache = stdenv.mkDerivation rec {
   checkPhase = ''
     export HOME=$(mktemp -d)
     ctest --output-on-failure ${lib.optionalString stdenv.isDarwin ''
-      -E '^(test.nocpp2|test.modules)$'
+      -E '^(test.nocpp2|test.modules|test.basedir|test.multi_arch)$'
     ''}
   '';
 
diff --git a/pkgs/development/tools/misc/ccache/env-instead-of-compgen.patch b/pkgs/development/tools/misc/ccache/env-instead-of-compgen.patch
new file mode 100644
index 000000000000..313de0fa58c3
--- /dev/null
+++ b/pkgs/development/tools/misc/ccache/env-instead-of-compgen.patch
@@ -0,0 +1,18 @@
+diff --git a/test/run b/test/run
+index cbdd98f0..bc930200 100755
+--- a/test/run
++++ b/test/run
+@@ -346,11 +346,11 @@ expect_perm() {
+ }
+ 
+ reset_environment() {
+-    while IFS= read -r name; do
++    while IFS='=' read -r name value; do
+         if [[ $name =~ ^CCACHE_[A-Z0-9_]*$ ]]; then
+             unset $name
+         fi
+-    done < <(compgen -e)
++    done < <(env)
+ 
+     unset GCC_COLORS
+     unset TERM