diff --git a/pkgs/development/python-modules/numdifftools/default.nix b/pkgs/development/python-modules/numdifftools/default.nix
new file mode 100644
index 000000000000..bc5914be721c
--- /dev/null
+++ b/pkgs/development/python-modules/numdifftools/default.nix
@@ -0,0 +1,51 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, numpy
+, pytestCheckHook
+, pythonOlder
+, scipy
+}:
+
+buildPythonPackage rec {
+  pname = "numdifftools";
+  version = "0.9.40";
+  format = "setuptools";
+
+  disabled = pythonOlder "3.7";
+
+  src = fetchFromGitHub {
+    owner = "pbrod";
+    repo = pname;
+    rev = "v${version}";
+    hash = "sha256-YLi9cNHcZ/PlhrhvYOMfRTOt4kinQcfxvqInT8/0Qpg=";
+  };
+
+  propagatedBuildInputs = [
+    numpy
+    scipy
+  ];
+
+  # Tests requires algopy and other modules which are optional and/or not available
+  doCheck = false;
+
+  postPatch = ''
+    substituteInPlace setup.py \
+      --replace '"pytest-runner"' ""
+    # Remove optional dependencies
+    substituteInPlace requirements.txt \
+      --replace "algopy>=0.4" "" \
+      --replace "statsmodels>=0.6" ""
+  '';
+
+  pythonImportsCheck = [
+    "numdifftools"
+  ];
+
+  meta = with lib; {
+    description = "Library to solve automatic numerical differentiation problems in one or more variables";
+    homepage = "https://github.com/pbrod/numdifftools";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 3d4ff7c5ebb8..5e8009a838db 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5862,6 +5862,8 @@ in {
 
   numcodecs = callPackage ../development/python-modules/numcodecs { };
 
+  numdifftools = callPackage ../development/python-modules/numdifftools { };
+
   numericalunits = callPackage ../development/python-modules/numericalunits { };
 
   numexpr = callPackage ../development/python-modules/numexpr { };