diff --git a/pkgs/development/libraries/science/biology/mirtk/default.nix b/pkgs/development/libraries/science/biology/mirtk/default.nix
index de419dc3d575..b6adf67cbe82 100644
--- a/pkgs/development/libraries/science/biology/mirtk/default.nix
+++ b/pkgs/development/libraries/science/biology/mirtk/default.nix
@@ -1,14 +1,27 @@
-{ lib, stdenv, gtest, fetchFromGitHub, cmake, boost, eigen, python3, vtk_8, zlib, tbb }:
+{ lib
+, stdenv
+, fetchFromGitHub
+, cmake
+, python3
+, boost
+, eigen
+, libGLU
+, fltk
+, itk
+, vtk
+, zlib
+, tbb
+}:
 
 stdenv.mkDerivation rec {
-  version = "2.0.0";
   pname = "mirtk";
+  version = "unstable-2022-07-22";
 
   src = fetchFromGitHub {
     owner = "BioMedIA";
     repo = "MIRTK";
-    rev = "v${version}";
-    sha256 = "0i2v97m66ir5myvi5b123r7zcagwy551b73s984gk7lksl5yiqxk";
+    rev = "973ce2fe3f9508dec68892dbf97cca39067aa3d6";
+    hash = "sha256-vKgkDrbyGOcbaYlxys1duC8ZNG0Y2nqh3TtSQ06Ox0Q=";
     fetchSubmodules = true;
   };
 
@@ -16,23 +29,36 @@ stdenv.mkDerivation rec {
     "-DWITH_VTK=ON"
     "-DBUILD_ALL_MODULES=ON"
     "-DWITH_TBB=ON"
+    "-DWITH_ITK=ON"
+    "-DWITH_GIFTICLIB=ON"
+    "-DWITH_NIFTILIB=ON"
   ];
 
-  doCheck = true;
-
-  checkPhase = ''
-    ctest -E '(Polynomial|ConvolutionFunction|Downsampling|EdgeTable|InterpolateExtrapolateImage)'
+  # tries to download data during configuration
+  postPatch = ''
+    substituteInPlace Packages/DrawEM/CMakeLists.txt --replace "include(Atlases.cmake)" ""
   '';
-  # testPolynomial - segfaults for some reason
-  # testConvolutionFunction, testDownsampling - main not called correctly
-  # testEdgeTable, testInterpolateExtrapolateImageFunction - setup fails
+
+  # tests don't seem to be maintained and gtest fails to link with BUILD_TESTING=ON;
+  # unclear if specific to Nixpkgs
+  doCheck = false;
 
   postInstall = ''
     install -Dm644 -t "$out/share/bash-completion/completions/mirtk" share/completion/bash/mirtk
   '';
 
-  nativeBuildInputs = [ cmake gtest ];
-  buildInputs = [ boost eigen python3 vtk_8 zlib tbb ];
+  nativeBuildInputs = [ cmake ];
+  buildInputs = [
+    boost
+    eigen
+    fltk
+    itk
+    libGLU.dev
+    python3
+    tbb
+    vtk
+    zlib
+  ];
 
   meta = with lib; {
     homepage = "https://github.com/BioMedIA/MIRTK";