diff --git a/pkgs/development/python-modules/transitions/default.nix b/pkgs/development/python-modules/transitions/default.nix
index 24bfa14b8c4b..42efd9d0017a 100644
--- a/pkgs/development/python-modules/transitions/default.nix
+++ b/pkgs/development/python-modules/transitions/default.nix
@@ -1,4 +1,5 @@
 { lib
+, stdenv
 , buildPythonPackage
 , fetchPypi
 , pythonAtLeast
@@ -38,6 +39,14 @@ buildPythonPackage rec {
     export HOME=$TMPDIR
   '';
 
+  # upstream issue https://github.com/pygraphviz/pygraphviz/issues/441
+  pytestFlagsArray = lib.optionals stdenv.isDarwin [
+    "--deselect=tests/test_pygraphviz.py::PygraphvizTest::test_binary_stream"
+    "--deselect=tests/test_pygraphviz.py::PygraphvizTest::test_diagram"
+    "--deselect=tests/test_pygraphviz.py::TestPygraphvizNested::test_binary_stream"
+    "--deselect=tests/test_pygraphviz.py::TestPygraphvizNested::test_diagram"
+  ];
+
   pythonImportsCheck = [
     "transitions"
   ];